Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base

Escherichia coli MutT hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, an event that can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA. Of the several enzymes that recognize 8-oxoguanine, MutT exhibits high substrate specificity for 8-oxoguanine nucleotides; however, the structural basis...

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Bibliographische Detailangaben
Hauptverfasser: Nakamura, Teruya, Meshitsuka, Sachiko, Kitagawa, Seiju, Abe, Nanase, Yamada, Junichi, Ishino, Tetsuya, Nakano, Hiroaki, Tsuzuki, Teruhisa, Doi, Takefumi, Kobayashi, Yuji, Fujii, Satoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804192/
https://ncbi.nlm.nih.gov/pubmed/19864691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066373
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