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Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

In this study, we tested five compounds belonging to a novel series of piperazine arylideneimidazolones for the ability to inhibit the AcrAB-TolC efflux pump. The biphenylmethylene derivative (BM-19) and the fluorenylmethylene derivative (BM-38) were found to possess the strongest efflux pump inhibi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Bohnert, Jürgen A., Schuster, Sabine, Kern, Winfried V., Karcz, Tadeusz, Olejarz, Agnieszka, Kaczor, Aneta, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808168/
https://ncbi.nlm.nih.gov/pubmed/26824939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01995-15
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