A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model

Many serious bacterial infections are difficult to treat due to biofilm formation, which provides physical protection and induces a sessile phenotype refractory to antibiotic treatment compared to the planktonic state. A key structural component of biofilm is extracellular DNA, which is held in plac...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Estellés, Angeles, Woischnig, Anne-Kathrin, Liu, Keyi, Stephenson, Robert, Lomongsod, Evelene, Nguyen, Da, Zhang, Jianzhong, Heidecker, Manfred, Yang, Yifan, Simon, Reyna J., Tenorio, Edgar, Ellsworth, Stote, Leighton, Anton, Ryser, Stefan, Gremmelmaier, Nina Khanna, Kauvar, Lawrence M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808150/
https://ncbi.nlm.nih.gov/pubmed/26833157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02588-15
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