Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

Overexpression of hypoxia-induced factor 1α (HIF-1α) has been shown to be involved in the development and progression of hepatocellular carcinoma (HCC). HIF-1α should therefore be a promising molecular target for the development of anti-HCC agents. Metformin, an established antidiabetic drug, has pr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zhou, Xinke, Chen, Jitao, Yi, Gao, Deng, Min, Liu, Hao, Liang, Min, Shi, Boyun, Fu, Xin, Chen, Yuqin, Chen, Liangcai, He, Zhimin, Wang, Jian, Liu, Jifang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808039/
https://ncbi.nlm.nih.gov/pubmed/26621849
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