Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AK...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Pappalardo, Francesco, Russo, Giulia, Candido, Saverio, Pennisi, Marzio, Cavalieri, Salvatore, Motta, Santo, McCubrey, James A., Nicoletti, Ferdinando, Libra, Massimo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807832/
https://ncbi.nlm.nih.gov/pubmed/27015094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152104
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