Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AK...

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Udgivet i:PLoS One
Main Authors: Pappalardo, Francesco, Russo, Giulia, Candido, Saverio, Pennisi, Marzio, Cavalieri, Salvatore, Motta, Santo, McCubrey, James A., Nicoletti, Ferdinando, Libra, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807832/
https://ncbi.nlm.nih.gov/pubmed/27015094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152104
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