Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

BACKGROUND: Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and molecular alterations able to activate the Ras/Raf/MEK/ERK (MAPK) and/or the PI3K/AK...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pappalardo, Francesco, Russo, Giulia, Candido, Saverio, Pennisi, Marzio, Cavalieri, Salvatore, Motta, Santo, McCubrey, James A., Nicoletti, Ferdinando, Libra, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807832/
https://ncbi.nlm.nih.gov/pubmed/27015094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152104
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