ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability

Secretory clusterin (sCLU) is a stress-induced, pro-survival glycoprotein elevated in early-stage cancers, in particular in APC/Min-defective colon cancers. sCLU is upregulated after exposure to various cytotoxic agents, including ionizing radiation (IR), leading to a survival advantage. We found th...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Goetz, EM, Shankar, B, Zou, Y, Morales, J, Luo, X, Araki, S, Bachoo, R, Mayo, LD, Boothman, DA
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807730/
https://ncbi.nlm.nih.gov/pubmed/21460853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.92
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