A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling

Evidence is accumulating for the role of cancer stem cells (CSCs) in mediating chemoresistance in patients with metastatic colorectal cancer (mCRC). A disintegrin and metalloproteinase domain 17 (ADAM17; also known as tumor necrosis factor-α-converting enzyme [TACE]) was shown to be overexpressed an...

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Udgivet i:Stem Cells Transl Med
Main Authors: Wang, Rui, Ye, Xiangcang, Bhattacharya, Rajat, Boulbes, Delphine R., Fan, Fan, Xia, Ling, Ellis, Lee M.
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2016
Fag:
Cancer Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807666/
https://ncbi.nlm.nih.gov/pubmed/26744411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0168
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