Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway

BACKGROUND: There is conflicting data on the role of macrophages in colorectal cancer (CRC); some studies have shown that macrophages can exert an anti-tumor effect whereas others show that macrophages are tumor promoting. We sought to determine the role of conditioned medium (CM) from macrophages,...

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Pubblicato in:PLoS One
Autori principali: Fan, Fan, Wang, Rui, Boulbes, Delphine R., Zhang, Huiyuan, Watowich, Stephanie S., Xia, Ling, Ye, Xiangcang, Bhattacharya, Rajat, Ellis, Lee M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749743/
https://ncbi.nlm.nih.gov/pubmed/29293549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190070
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