β-Lapachone-mediated Apoptosis in Human Promyelocytic Leukemia (HL-60) and Human Prostate Cancer Cells: A p53-independent Response()

(β) -Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K(+) assays. We show that β-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Planchon, Sarah M., Wuerzberger, Shelly, Frydman, Benjamin, Witiak, Donald T., Hutson, Paul, Church, Dawn R., Wilding, George, Boothman, David A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1995
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807624/
https://ncbi.nlm.nih.gov/pubmed/7641180
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak