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β-Lapachone-mediated Apoptosis in Human Promyelocytic Leukemia (HL-60) and Human Prostate Cancer Cells: A p53-independent Response()
(β) -Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K(+) assays. We show that β-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Cancer Res |
|---|---|
| Prif Awduron: | , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
1995
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807624/ https://ncbi.nlm.nih.gov/pubmed/7641180 |
| Tagiau: |
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