β-Lapachone-mediated Apoptosis in Human Promyelocytic Leukemia (HL-60) and Human Prostate Cancer Cells: A p53-independent Response()

(β) -Lapachone and certain of its derivatives directly bind and inhibit topoisomerase I (Topo I) DNA unwinding activity and form DNA-Topo I complexes, which are not resolvable by SDS-K(+) assays. We show that β-lapachone can induce apoptosis in certain cells, such as in human promyelocytic leukemia...

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Vydáno v:Cancer Res
Hlavní autoři: Planchon, Sarah M., Wuerzberger, Shelly, Frydman, Benjamin, Witiak, Donald T., Hutson, Paul, Church, Dawn R., Wilding, George, Boothman, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807624/
https://ncbi.nlm.nih.gov/pubmed/7641180
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