Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model

BACKGROUND: The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis, angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including glioblastoma (GBM), the most common and fatal brain cancer. In the present study, we evaluated the effects of peptide R, a ne...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Mercurio, Laura, Ajmone-Cat, Maria Antonietta, Cecchetti, Serena, Ricci, Alessandro, Bozzuto, Giuseppina, Molinari, Agnese, Manni, Isabella, Pollo, Bianca, Scala, Stefania, Carpinelli, Giulia, Minghetti, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807593/
https://ncbi.nlm.nih.gov/pubmed/27015814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0326-y
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