PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM

Pseudomonas aeruginosa produces a number of alkylquinolone-type secondary metabolites best known for their antimicrobial effects and involvement in cell-cell communication. In the alkylquinolone biosynthetic pathway, the β-ketoacyl-(acyl carrier protein) synthase III (FabH)-like enzyme PqsBC catalyz...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Drees, Steffen Lorenz, Li, Chan, Prasetya, Fajar, Saleem, Muhammad, Dreveny, Ingrid, Williams, Paul, Hennecke, Ulrich, Emsley, Jonas, Fetzner, Susanne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807248/
https://ncbi.nlm.nih.gov/pubmed/26811339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708453
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