Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability

The 2-alkyl-3-hydroxy-4(1H)-quinolone 2,4-dioxygenase HodC was previously described to cleave the Pseudomonas quinolone signal, PQS, which is exclusively used in the complex quorum sensing (QS) system of Pseudomonas aeruginosa, an opportunistic pathogen employing QS to regulate virulence and biofilm...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Tettmann, Beatrix, Niewerth, Christine, Kirschhöfer, Frank, Neidig, Anke, Dötsch, Andreas, Brenner-Weiss, Gerald, Fetzner, Susanne, Overhage, Joerg
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145850/
https://ncbi.nlm.nih.gov/pubmed/28018312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.01978
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