PqsL uses reduced flavin to produce 2-hydroxylaminobenzoylacetate, a preferred PqsBC substrate in alkyl quinolone biosynthesis in Pseudomonas aeruginosa

Alkyl hydroxyquinoline N-oxides (AQNOs) are antibiotic compounds produced by the opportunistic bacterial pathogen Pseudomonas aeruginosa. They are products of the alkyl quinolone (AQ) biosynthetic pathway, which also generates the quorum-sensing molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Drees, Steffen Lorenz, Ernst, Simon, Belviso, Benny Danilo, Jagmann, Nina, Hennecke, Ulrich, Fetzner, Susanne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005433/
https://ncbi.nlm.nih.gov/pubmed/29669807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000789
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