Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

Hierarchic phosphorylation and concomitant Pin1-mediated proline isomerization of the oncoprotein c-Myc controls its cellular stability and activity. However, the molecular basis for Pin1 recognition and catalysis of c-Myc and other multisite, disordered substrates in cell regulation and disease is...

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Publicat a:Structure
Autors principals: Helander, Sara, Montecchio, Meri, Pilstål, Robert, Su, Yulong, Kuruvilla, Jacob, Elvén, Malin, Ziauddin, Javed M.E., Anandapadamanaban, Madhanagopal, Cristobal, Susana, Lundström, Patrik, Sears, Rosalie C., Wallner, Björn, Sunnerhagen, Maria
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807222/
https://ncbi.nlm.nih.gov/pubmed/26655473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.10.010
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