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Proton-sensing GPCR-YAP Signalling Promotes Cancer-associated Fibroblast Activation of Mesenchymal Stem Cells

The pHs of extracellular fluids (ECFs) in normal tissues are commonly maintained at 7.35 to 7.45. The acidification of the ECF is one of the major characteristics of tumour microenvironment. In this study, we report that decreased extracellular pH promotes the transformation of mesenchymal stem cell...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Zhu, Hongyi, Guo, Shangchun, Zhang, Yuelei, Yin, Junhui, Yin, Wenjing, Tao, Shicong, Wang, Yang, Zhang, Changqing
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807159/
https://ncbi.nlm.nih.gov/pubmed/27019624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13688
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