Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.

A series of methotrexate (MTX)-resistant L1210 leukemia murine ascites tumors were developed in vivo and analyzed for drug resistance. Three of 20 tumors studied expressed an altered dihydrofolate reductase (DHFR) and each was identical, having a C to T base transition at nucleotide 46 in the DHFR g...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Dicker, A P, Waltham, M C, Volkenandt, M, Schweitzer, B I, Otter, G M, Schmid, F A, Sirotnak, F M, Bertino, J R
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 1993
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48071/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11797
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