Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.

A series of methotrexate (MTX)-resistant L1210 leukemia murine ascites tumors were developed in vivo and analyzed for drug resistance. Three of 20 tumors studied expressed an altered dihydrofolate reductase (DHFR) and each was identical, having a C to T base transition at nucleotide 46 in the DHFR g...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Dicker, A P, Waltham, M C, Volkenandt, M, Schweitzer, B I, Otter, G M, Schmid, F A, Sirotnak, F M, Bertino, J R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48071/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11797
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