Mitigation of Myocardial Fibrosis by Molecular Cardiac Surgery Mediated Gene Overexpression

OBJECTIVE: Heart failure is accompanied by upregulation of transforming growth factor beta signaling, accumulation of collagen and dysregulation of sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a). We examined the fibrotic response in small and large myocardial infarct and the effe...

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Bibliographic Details
Published in:J Thorac Cardiovasc Surg
Main Authors: Katz, Michael G, Brandon-Warner, Elizabeth, Fargnoli, Anthony S, Williams, Richard D, Kendle, Andrew P, Hajjar, Roger J, Schrum, Laura W, Bridges, Charles R
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805528/
https://ncbi.nlm.nih.gov/pubmed/26769537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2015.11.031
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