Mitigation of Myocardial Fibrosis by Molecular Cardiac Surgery Mediated Gene Overexpression

OBJECTIVE: Heart failure is accompanied by upregulation of transforming growth factor beta signaling, accumulation of collagen and dysregulation of sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a). We examined the fibrotic response in small and large myocardial infarct and the effe...

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Gepubliceerd in:J Thorac Cardiovasc Surg
Hoofdauteurs: Katz, Michael G, Brandon-Warner, Elizabeth, Fargnoli, Anthony S, Williams, Richard D, Kendle, Andrew P, Hajjar, Roger J, Schrum, Laura W, Bridges, Charles R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805528/
https://ncbi.nlm.nih.gov/pubmed/26769537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2015.11.031
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