Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart Failure

The advancement of gene therapy–based approaches to treat heart disease represents a need for clinically relevant animal models with characteristics equivalent to human pathologies. Rodent models of cardiac disease do not precisely reproduce heart failure phenotype and molecular defects. This has mo...

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Bibliografische gegevens
Gepubliceerd in:Hum Gene Ther Clin Dev
Hoofdauteurs: Katz, Michael G., Fargnoli, Anthony S., Weber, Thomas, Hajjar, Roger J., Bridges, Charles R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2017
Onderwerpen:
Special Focus: Preclinical Studies in Large Animals
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655838/
https://ncbi.nlm.nih.gov/pubmed/28726495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.070
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