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Targeting Glycolysis in Leukemia: A novel inhibitor 3-BrOP in combination with Rapamycin

Rapidly proliferating solid tumor cells are often dependent on glycolysis for ATP production even in normoxia (the Warburg effect), however it is not yet clear whether acute leukemias have a similarly increased dependence on aerobic glycolysis. We report that all leukemia subtypes (pre-B ALL, T-ALL...

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Publicado en:Leuk Res
Autores principales: Akers, Lauren J., Fang, Wendy, Levy, Alejandro G., Franklin, Anna R., Huang, Peng, Zweidler-McKay, Patrick A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805370/
https://ncbi.nlm.nih.gov/pubmed/21316758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.12.028
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