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Targeting Glycolysis in Leukemia: A novel inhibitor 3-BrOP in combination with Rapamycin

Rapidly proliferating solid tumor cells are often dependent on glycolysis for ATP production even in normoxia (the Warburg effect), however it is not yet clear whether acute leukemias have a similarly increased dependence on aerobic glycolysis. We report that all leukemia subtypes (pre-B ALL, T-ALL...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Leuk Res
Prif Awduron: Akers, Lauren J., Fang, Wendy, Levy, Alejandro G., Franklin, Anna R., Huang, Peng, Zweidler-McKay, Patrick A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805370/
https://ncbi.nlm.nih.gov/pubmed/21316758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.12.028
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