Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

To speed drug discovery, we developed an approach for identification of individual peptides with a desired biological activity from a library containing millions of peptides. The approach uses sequential orthogonal release of chemically synthesized peptides from insoluble beads, followed by testing...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Salmon, S E, Lam, K S, Lebl, M, Kandola, A, Khattri, P S, Wade, S, Pátek, M, Kocis, P, Krchnák, V, Thorpe, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8265613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.24.11708
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