IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy

IL-2 is a lymphocyte growth factor that is an important component of many immune-based cancer therapies. The efficacy of IL-2 is thought to be limited by the expansion of T regulatory cells, which express the high affinity IL-2 receptor subunit, IL-2Rα. IL-15 is under investigation as an alternative...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Su, Ee W., Moore, Caitlin J., Suriano, Samantha, Johnson, Christopher B., Songalia, Neizel, Patterson, Alicia, Neitzke, Daniel J., Andrijauskaite, Kristina, Garrett-Mayer, Elizabeth, Mehrotra, Shikhar, Paulos, Chrystal M., Doedens, Andrew L., Goldrath, Ananda W., Li, Zihai, Cole, David J., Rubinstein, Mark P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805116/
https://ncbi.nlm.nih.gov/pubmed/26511507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8155
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