Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy

IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and a...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Johnson, C. Bryce, Wrangle, John, Mehrotra, Shikhar, Li, Zihai, Paulos, Chrystal M., Cole, David J., Surh, Charles D., Rubinstein, Mark P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910714/
https://ncbi.nlm.nih.gov/pubmed/27467935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1122865
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