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Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and a...
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| Publicado no: | Oncoimmunology |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4910714/ https://ncbi.nlm.nih.gov/pubmed/27467935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1122865 |
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