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Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment

Ligand-directed signaling, biased agonism, and functional selectivity are terms that describe the propensity of a ligand to drive signaling toward one GPCR pathway over another. Most of the early examples demonstrated to date examine the divergence between GPCR signaling to G protein coupling and βa...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Bohn, Laura M., Zhou, Lei, Ho, Jo-Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804702/
https://ncbi.nlm.nih.gov/pubmed/26260601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-2914-6_12
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