Different states of synaptotagmin regulate evoked versus spontaneous release

The tandem C2-domains of synaptotagmin 1 (syt) function as Ca(2+)-binding modules that trigger exocytosis; in the absence of Ca(2+), syt inhibits spontaneous release. Here, we used proline linkers to constrain and alter the relative orientation of these C2-domains. Short poly-proline helices have a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Bai, Hua, Xue, Renhao, Bao, Huan, Zhang, Leili, Yethiraj, Arun, Cui, Qiang, Chapman, Edwin R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804166/
https://ncbi.nlm.nih.gov/pubmed/27001899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10971
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk