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Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein

Prion diseases are fatal neurodegenerative disorders for which there is no effective treatment. Because the cellular prion protein (PrP(C)) is required for propagation of the infectious scrapie form of the protein, one therapeutic strategy is to reduce PrP(C) expression. Recently FK506, an inhibitor...

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Bibliografske podrobnosti
izdano v:Mol Biol Cell
Main Authors: Stocki, Pawel, Sawicki, Maxime, Mays, Charles E., Hong, Seo Jung, Chapman, Daniel C., Westaway, David, Williams, David B.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803302/
https://ncbi.nlm.nih.gov/pubmed/26764098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0729
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