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Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein

Prion diseases are fatal neurodegenerative disorders for which there is no effective treatment. Because the cellular prion protein (PrP(C)) is required for propagation of the infectious scrapie form of the protein, one therapeutic strategy is to reduce PrP(C) expression. Recently FK506, an inhibitor...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Stocki, Pawel, Sawicki, Maxime, Mays, Charles E., Hong, Seo Jung, Chapman, Daniel C., Westaway, David, Williams, David B.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803302/
https://ncbi.nlm.nih.gov/pubmed/26764098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-10-0729
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