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Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation

The endothelial junction is tightly controlled to restrict the passage of blood cells and solutes. Disruption of endothelial barrier function by bacterial endotoxins, cytokines or growth factors results in inflammation and vascular damage leading to vascular diseases. We have identified 5-methoxytry...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chu, Ling-Yun, Wang, Yi-Fu, Cheng, Huei-Hsuan, Kuo, Cheng-Chin, Wu, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803234/
https://ncbi.nlm.nih.gov/pubmed/27002329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152166
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