Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan

Cyclooxygenase-2 (COX-2) expression is induced by mitogenic and proinflammatory factors. Its overexpression plays a causal role in inflammation and tumorigenesis. COX-2 expression is tightly regulated, but the mechanisms are largely unclear. Here we show the control of COX-2 expression by an endogen...

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Bibliografiska uppgifter
Huvudupphovsmän: Cheng, Huei-Hsuan, Kuo, Cheng-Chin, Yan, Jiann-Long, Chen, Hua-Ling, Lin, Wei-Chung, Wang, Kai-Hsuan, Tsai, Kelvin K.-C., Guvén, Hayrettin, Flaberg, Emilie, Szekely, Laszlo, Klein, George, Wu, Kenneth K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421199/
https://ncbi.nlm.nih.gov/pubmed/22851770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209919109
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