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Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity
BACKGROUND: Dnmt3a is a DNA methyltransferase that establishes de novo DNA methylation in mammals. The structure of the Dnmt3a C-terminal domain is similar to the bacterial M. HhaI enzyme, a well-studied prokaryotic DNA methyltransferase. No X-ray structure is available for the complex of Dnmt3a wit...
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| Publicado no: | BMC Biochem |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4802922/ https://ncbi.nlm.nih.gov/pubmed/27001594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-016-0064-y |
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