BRCA testing, treatment patterns and survival in platinum-sensitive recurrent ovarian cancer – an observational cohort study

BACKGROUND: Breast cancer associated (BRCA) genes are critical for DNA repair. Mutations in BRCA1 and BRCA2 (BRCAm) result in loss of these repair mechanisms and potential carcinogenesis. Germline BRCAm are common in ovarian carcinomas, particularly in platinum-sensitive disease. The increased preva...

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Detalhes bibliográficos
Publicado no:J Ovarian Res
Main Authors: Unni, Sudhir K., Schauerhamer, Marisa B., Deka, Rishi, Tyczynski, Jerzy E., Fernandes, Ancilla W., Stevens, Vanessa, Brixner, Diana I., Stenehjem, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802840/
https://ncbi.nlm.nih.gov/pubmed/27004793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-016-0227-x
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