Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA

The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human bacterial pathogen Listeria monocytogenes. Phenotypic screening identified ring-fused 2-pyridone molecules that at low micromolar concentrati...

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Publicat a:Cell Chem Biol
Autors principals: Good, James A.D., Andersson, Christopher, Hansen, Sabine, Wall, Jessica, Krishnan, K. Syam, Begum, Afshan, Grundström, Christin, Niemiec, Moritz S., Vaitkevicius, Karolis, Chorell, Erik, Wittung-Stafshede, Pernilla, Sauer, Uwe H., Sauer-Eriksson, A. Elisabeth, Almqvist, Fredrik, Johansson, Jörgen
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802734/
https://ncbi.nlm.nih.gov/pubmed/26991105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.02.013
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