Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA

ABSTRACT: G-quadruplexes are non-canonical DNA structures formed by guanine-rich DNA sequences that are implicated in cancer and aging. Understanding how small molecule ligands interact with quadruplexes is essential both to the development of novel anticancer therapeutics and to the design of new q...

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Bibliographic Details
Published in:J Biol Inorg Chem
Main Authors: Sabharwal, Navin C., Mendoza, Oscar, Nicoludis, John M., Ruan, Thomas, Mergny, Jean-Louis, Yatsunyk, Liliya A.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801998/
https://ncbi.nlm.nih.gov/pubmed/26748794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-015-1325-8
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