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Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-quadruplex DNA

ABSTRACT: G-quadruplexes are non-canonical DNA structures formed by guanine-rich DNA sequences that are implicated in cancer and aging. Understanding how small molecule ligands interact with quadruplexes is essential both to the development of novel anticancer therapeutics and to the design of new q...

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Detalhes bibliográficos
Publicado no:J Biol Inorg Chem
Main Authors: Sabharwal, Navin C., Mendoza, Oscar, Nicoludis, John M., Ruan, Thomas, Mergny, Jean-Louis, Yatsunyk, Liliya A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801998/
https://ncbi.nlm.nih.gov/pubmed/26748794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-015-1325-8
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