SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma

Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, that are associated with advanced stage lung cancers and are implicated in the...

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Publicado en:Oncogene
Autores principales: Luanpitpong, Sudjit, Li, Jingting, Manke, Amruta, Brundage, Kathleen, Ellis, Emily, McLaughlin, Sarah L., Angsutararux, Paweorn, Chanthra, Nawin, Voronkova, Maria, Chen, Yi Charlie, Wang, Liying, Chanvorachote, Pithi, Pei, Ming, Issaragrisil, Surapol, Rojanasakul, Yon
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801727/
https://ncbi.nlm.nih.gov/pubmed/26387547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.351
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