SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma

Cancer stem cells (CSCs) are a promising target for cancer therapy, particularly for metastatic lung cancers, but how CSCs are regulated is largely unknown. We identify two proteins, SLUG (encoded by SNAI2 gene) and SOX9, that are associated with advanced stage lung cancers and are implicated in the...

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Veröffentlicht in:Oncogene
Hauptverfasser: Luanpitpong, Sudjit, Li, Jingting, Manke, Amruta, Brundage, Kathleen, Ellis, Emily, McLaughlin, Sarah L., Angsutararux, Paweorn, Chanthra, Nawin, Voronkova, Maria, Chen, Yi Charlie, Wang, Liying, Chanvorachote, Pithi, Pei, Ming, Issaragrisil, Surapol, Rojanasakul, Yon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801727/
https://ncbi.nlm.nih.gov/pubmed/26387547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.351
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