A new view of transcriptome complexity and regulation through the lens of local splicing variations

Alternative splicing (AS) can critically affect gene function and disease, yet mapping splicing variations remains a challenge. Here, we propose a new approach to define and quantify mRNA splicing in units of local splicing variations (LSVs). LSVs capture previously defined types of alternative spli...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Vaquero-Garcia, Jorge, Barrera, Alejandro, Gazzara, Matthew R, González-Vallinas, Juan, Lahens, Nicholas F, Hogenesch, John B, Lynch, Kristen W, Barash, Yoseph
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801060/
https://ncbi.nlm.nih.gov/pubmed/26829591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11752
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