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Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform

RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure e...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nguyen, Nhung T.H., Now, Hesung, Kim, Woo-Jong, Kim, Nari, Yoo, Joo-Yeon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800306/
https://ncbi.nlm.nih.gov/pubmed/26996158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23377
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