Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism

Therapy resistance remains a major problem in estrogen receptor-α (ERα)-positive breast cancer. A subgroup of ERα-positive breast cancer is characterized by mosaic presence of a minor population of ERα-negative cancer cells expressing the basal cytokeratin-5 (CK5). These CK5-positive cells are thera...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Goodman, C R, Sato, T, Peck, A R, Girondo, M A, Yang, N, Liu, C, Yanac, A F, Kovatich, A J, Hooke, J A, Shriver, C D, Mitchell, E P, Hyslop, T, Rui, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4800289/
https://ncbi.nlm.nih.gov/pubmed/26096934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.193
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