Pharmacokinetic/pharmaco–dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ(9)‐tetrahydrocannabinol challenge tests

AIM: The severe psychiatric side effects of cannabinoid receptor type 1 (CB(1)) antagonists hampered their wide development but this might be overcome by careful management of drug development with pharmacokinetic/pharmacodynamic (PK/PD) analyses. PK/PD models suitable for direct comparison of diffe...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Guan, Zheng, Klumpers, Linda E., Oyetayo, Olubukayo‐Opeyemi, Heuberger, Jules, van Gerven, Joop M. A., Stevens, Jasper
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
PK‐PD Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799916/
https://ncbi.nlm.nih.gov/pubmed/26617196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12852
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