Conversion of leucine to β‐hydroxy‐β‐methylbutyrate by α‐keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

BACKGROUND: L‐Leu and its metabolite β‐hydroxy‐β‐methylbutyrate (HMB) stimulate muscle protein synthesis enhancing the phosphorylation of proteins that regulate anabolic signalling pathways. Alterations in these pathways are observed in many catabolic diseases, and HMB and L‐Leu have proven their an...

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Bibliografske podrobnosti
izdano v:J Cachexia Sarcopenia Muscle
Main Authors: Girón, María D., Vílchez, José D., Salto, Rafael, Manzano, Manuel, Sevillano, Natalia, Campos, Nefertiti, Argilés, Josep M., Rueda, Ricardo, López‐Pedrosa, José M.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799859/
https://ncbi.nlm.nih.gov/pubmed/27065075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12032
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