Conversion of leucine to β‐hydroxy‐β‐methylbutyrate by α‐keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

BACKGROUND: L‐Leu and its metabolite β‐hydroxy‐β‐methylbutyrate (HMB) stimulate muscle protein synthesis enhancing the phosphorylation of proteins that regulate anabolic signalling pathways. Alterations in these pathways are observed in many catabolic diseases, and HMB and L‐Leu have proven their an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Cachexia Sarcopenia Muscle
Main Authors: Girón, María D., Vílchez, José D., Salto, Rafael, Manzano, Manuel, Sevillano, Natalia, Campos, Nefertiti, Argilés, Josep M., Rueda, Ricardo, López‐Pedrosa, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799859/
https://ncbi.nlm.nih.gov/pubmed/27065075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12032
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados