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Origins of Programmable Nucleases for Genome Engineering
Genome engineering with programmable nucleases depends on cellular responses to a targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger nucleases (ZFNs) that showed that arbitrary DNA sequences could be addressed for cleavage by protein engineering, ushering in...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4798875/ https://ncbi.nlm.nih.gov/pubmed/26506267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.10.014 |
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