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Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.

Sequential expression of the genes of the human beta-globin locus requires the formation of an erythroid-specific chromatin domain spanning > 200 kb. Regulation of this gene family involves both local interactions with proximal cis-acting sequences and long-range interactions with control elements u...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gaensler, K M, Kitamura, M, Kan, Y W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47986/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248258/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.23.11381
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