The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.
We linked a 3.3-kilobase fragment containing the entire A gamma-globin gene together with 1.3 kilobases of 5' flanking and 0.37 kilobase of 3' flanking DNA to a 2.5-kilobase fragment containing four of the developmentally stable hypersensitive sites normally located in the 5' region of the human bet...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1989
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC297987/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2476809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.18.7033 |
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